Details
Biochemistry and Cell Biology of Ageing: Part III Biomedical Science
Subcellular Biochemistry, Band 102
|
181,89 € |
|
| Verlag: | Springer |
| Format: | |
| Veröffentl.: | 04.01.2023 |
| ISBN/EAN: | 9783031214103 |
| Sprache: | englisch |
Dieses eBook enthält ein Wasserzeichen.
Beschreibungen
<p>This book provides a state-of-the-art overview of key areas of subcellular aging research in human cells.</p>
<p>The reader is introduced to the historical development and progress in biomedical aging research and learns, for example, about the role of microRNAs, circRNAs, mitochondria and extracellular vesicles in cellular senescence. The reader will also learn more about how gap junctions, the nuclear pore complex and the proteasome are affecting the ageing processes. In addition, novel therapeutic opportunities through modulation of cellular senescence are discussed.</p>
<p>The book follows on from Parts I and II of <i>Biochemistry and Cell Biology of Ageing</i> (Volumes 90 and 91 of the <i>Subcellular Biochemistry</i> book series) by covering interesting and significant biomedical ageing topics not included in the earlier volumes. Comprehensive and cutting-edge, this book is a valuable resource for experienced researchers and early career scientist alike, who are interested in learning more about the fascinating and challenging question of why and how our cells age.</p><br><p></p>
<p>The reader is introduced to the historical development and progress in biomedical aging research and learns, for example, about the role of microRNAs, circRNAs, mitochondria and extracellular vesicles in cellular senescence. The reader will also learn more about how gap junctions, the nuclear pore complex and the proteasome are affecting the ageing processes. In addition, novel therapeutic opportunities through modulation of cellular senescence are discussed.</p>
<p>The book follows on from Parts I and II of <i>Biochemistry and Cell Biology of Ageing</i> (Volumes 90 and 91 of the <i>Subcellular Biochemistry</i> book series) by covering interesting and significant biomedical ageing topics not included in the earlier volumes. Comprehensive and cutting-edge, this book is a valuable resource for experienced researchers and early career scientist alike, who are interested in learning more about the fascinating and challenging question of why and how our cells age.</p><br><p></p>
<div><div>Chapter 1: Introduction: Progression of the Science of Ageing.- Chapter 2: Chromatin structure from development to ageing.- Chapter 3: The nuclear envelope in ageing and progeria.- Chapter 4: Mitochondrial DNA mutations and ageing.- Chapter 5: The Proteasome and Ageing.- Chapter 6: Gap junctions and Ageing.- Chapter 7: Cellular senescence and ageing.- Chapter 8: Therapeutic opportunities presented by modulation of cellular senescence.- Chapter 9: Ageing at Molecular Level: Role of MicroRNAs.- Chapter 10: CircRNAandAgeing.- Chapter 11: Extracellular vesicles and cellular ageing.- Chapter 12: Fibrinogen, Coagulation and Ageing.- Chapter 13: An Insight intoPlateletsat Older Age:Cellular and Clinical Perspectives.- Chapter 14: Ageing skeletal muscle: The ubiquitous muscle stem cell.- Chapter 15: Age-related changes in central nervous system 5-hydroxytryptamine signalling and its potential effects on the regulation of lifespan.- Chapter 16: Systems Biology of Ageing.</div><div><br></div><div><br></div><div><br></div><div><br></div><div><br></div><div><br></div><div><br></div><div><br></div><div><br></div><div><br></div><div><br></div><div><br></div><div><br></div><div><br></div><div><br></div></div>
<p><b>Prof J. Robin Harris</b> is an Honorary Professor of the University of Mainz, who specialized in macromolecular electron microscopy. He has been the Series Editor of the Subcellular Biochemistry Series for many years and his broad scientific interests are reflected in the diversity of content of the Series.</p><b> Dr Viktor Korolchuk</b> is Reader in Molecular Cell Biology at Newcastle University. His scientific interests lie in the area of intracellular protein trafficking and degradation pathways. The current focus of research in his laboratory is autophagy (literally self-eating) where portions of cytoplasm are recruited into intracellular vesicles called autophagosomes and transported for degradation by lysosomal hydrolases. <div><div><br></div></div>
<div><p></p><p>This, our third book on the Biochemistry and Cell Biology of Ageing in the <i>Subcellular Biochemistry</i> series, expands on the content of Part I, by covering additional biomedical topics. The 16 chapters included here, contributed by international knowledgeable scientists, review these further interesting topics at an advanced level.</p>
<p>Following an Introductory chapter, these topics are included: Chromatin Structure from Development to Ageing, the Nuclear Envelope in Ageing and Progeria, Mitochondrial DNA Mutations and Ageing, the Proteasome and Ageing, Gap Junctions and Ageing, Cellular Senescence and Ageing, Therapeutic Opportunities Presented by Modulation of Cellular Senescence, Ageing at Molecular Level: Role of MicroRNAs, CircRNA and Ageing, Extracellular Vesicles and Cellular Ageing,Fibrinogen, Coagulation and Ageing, An Insight into Platelets at Older Age: Cellular and Clinical Perspectives, Ageing Skeletal Muscle: The Ubiquitous Muscle Stem Cell,Age-related Changes in Central Nervous System 5-Hydroxytryptamine Signalling and its Potential effects on the Regulation of Lifespan, and Systems Biology of Ageing. </p>
<p>The book is primarily directed to advanced biomedical science and medical students, postgraduates, researchers and academics in the field of Ageing. A further companion volume of the series (Part IV) covering the more Clinical Science aspects will be published soon. The seemingly endless expansion of ageing research continues to throw up important areas, that may well be covered in future volumes, together with updates of rapidly moving subjects. Thus, a further book on Anti-ageing Interventions (Part V) is under production.</p><br><p></p></div>
<p>Following an Introductory chapter, these topics are included: Chromatin Structure from Development to Ageing, the Nuclear Envelope in Ageing and Progeria, Mitochondrial DNA Mutations and Ageing, the Proteasome and Ageing, Gap Junctions and Ageing, Cellular Senescence and Ageing, Therapeutic Opportunities Presented by Modulation of Cellular Senescence, Ageing at Molecular Level: Role of MicroRNAs, CircRNA and Ageing, Extracellular Vesicles and Cellular Ageing,Fibrinogen, Coagulation and Ageing, An Insight into Platelets at Older Age: Cellular and Clinical Perspectives, Ageing Skeletal Muscle: The Ubiquitous Muscle Stem Cell,Age-related Changes in Central Nervous System 5-Hydroxytryptamine Signalling and its Potential effects on the Regulation of Lifespan, and Systems Biology of Ageing. </p>
<p>The book is primarily directed to advanced biomedical science and medical students, postgraduates, researchers and academics in the field of Ageing. A further companion volume of the series (Part IV) covering the more Clinical Science aspects will be published soon. The seemingly endless expansion of ageing research continues to throw up important areas, that may well be covered in future volumes, together with updates of rapidly moving subjects. Thus, a further book on Anti-ageing Interventions (Part V) is under production.</p><br><p></p></div>
Informs on the biochemistry and cellular biology of aging processes in human cells Introduces the historical development and progression in biomedical aging research Discusses novel therapeutic opportunities through modulation of cellular senescence
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